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Data & statistics on Bone Metastases Therapy – 45 results
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Imaging tumor-immune cell propinquity. (A) Experimental design. Immunodeficient mice (nu/nu) were irradiated, and bone marrow was transplanted from β-gal–expressing transgenic mice, activator, or control mice. Three weeks after bone marrow transplantation (BMT), 4T1-luc2 reporter mammary carcinoma cells (1 × 104) were orthotopically allografted into the mammary fat pads of all animals. Metastases development ...

Imaging tumor-immune cell propinquity. (A) Experimental design. Immunodeficient mice (nu/nu) were irradiated, and bone marrow was transplanted from β-gal–expressing transgenic mice, activator, or ...

www.pnas.org/content/early/2013/05/01/1218336110.full.pdf

understanding of micrometastasis development and help identify new therapies to combat ...
Histolgy Metastases Imaging Primary Pulmonary Lymph Time (Week) C control M1 control M2 ...
(A) Experimental design. Immunodeficient mice (nu/nu) were irradiated, and bone marrow

May 2013 | Proceedings of the National Academy of Sciences
Original Url: http://www.pnas.org/content/early/2013/05/01/1218336110.full.pdf
Osteoblastic bone metastases from MCF-7 and T47D are mediated by ET-1. (A) Histology of bones affected with osteoblastic metastases from MCF-7 and T47D. Tumor cells and new bone partially fill the marrow space in the sections from T47D-bearing mice (Right), whereas tumor and new bone have completely replaced the vertebral body marrow space in mice inoculated with MCF-7 (Center). (B) (Upper) Effects ...

Osteoblastic bone metastases from MCF-7 and T47D are mediated by ET-1. (A) Histology of bones affected with osteoblastic metastases from MCF-7 and T47D. Tumor cells and new bone partially fill the ...

www.pnas.org/content/100/19/10954.full.pdf

Effects of ABT-627 on Osteoblastic Bone Metastases. Mice were divided into six groups (n 5 per group). Groups consisted of control PBS (groups a and d), ABT-627 ...
was added to drinking water. Radiography, bone and soft tissue harvest, and autopsy

Sep 2003 | Proceedings of the National Academy of Sciences
Original Url: http://www.pnas.org/content/100/19/10954.full.pdf
Phenotype of bone metastases. (A) Radiographs of long bone and spine. (Upper) Hind limbs from mice inoculated with PBS (Left), MDA-MB-231 (Center), and ZR-75-1 (Right). (Lower) Spines. No lesions are evident in the PBS group (Left). Arrows designate osteolytic lesions in the MDA-MB-231 group (Center) and osteoblastic lesions in the ZR-75-1 group (Right). (B) Histology of distal femur from mice given ...

Phenotype of bone metastases. (A) Radiographs of long bone and spine. (Upper) Hind limbs from mice inoculated with PBS (Left), MDA-MB-231 (Center), and ZR-75-1 (Right). (Lower) Spines. No lesions are ...

www.pnas.org/content/100/19/10954.full.pdf

new bone formation at sites of metastases, including insulin-like growth factors ...
were higher in men with advanced prostate cancer with bone metastases compared with men ...
1 in the pathogenesis of osteoblastic metastases, but a causal role for ET-1 in bone metastasis

Jan 2003 | Proceedings of the National Academy of Sciences
Original Url: http://www.pnas.org/content/100/19/10954.full.pdf
Activated integrin v 3 enhances matrix-directed breast cancer cell migration. (A) Migration of MDA-MB 435 human breast cancer cells (Parent), their in vivo-selected metastatic variant from a bone metastase in the SCID mouse model (Bone), or their in vitro generated variants that lack 3 integrin expression ( 3minus) were transfected to express either the 3 wild-type gene ( 3WT) or the constitutively ...

Activated integrin v 3 enhances matrix-directed breast cancer cell migration. (A) Migration of MDA-MB 435 human breast cancer cells (Parent), their in vivo-selected metastatic variant from a bone ...

www.pnas.org/content/100/16/9482.full.pdf

Results Activated Integrin v 3 Enhances Matrix-Directed Breast Cancer Cell Migration. Expression of integrin v 3 in a constitutively activated functional form strongly enhances metastasis of human breast cancer cells (9). To analyze mechanisms ... ...
italy ...
2003

Jan 2003 | Proceedings of the National Academy of Sciences
Original Url: http://www.pnas.org/content/100/16/9482.full.pdf
ET-1 production by cancer lines that cause bone metastases

ET-1 production by cancer lines that cause bone metastases

www.pnas.org/content/100/19/10954.full.pdf

Effects of ABT-627 on Osteoblastic Bone Metastases. Mice were divided into six groups (n 5 per group). Groups consisted of control PBS (groups a and d), ABT-627 ...
was added to drinking water. Radiography, bone and soft tissue harvest, and autopsy ...
ET-1, pg ml per 105 cells per 48 h [PTHrP], pM per 105 cells per 48 h Bone metastases Cell line Breast cancers ZR-75-1 MCF-7 T47D BT483 MDA-MB-231 BT549 MDA-MB-435s

Sep 2003 | Proceedings of the National Academy of Sciences
Original Url: http://www.pnas.org/content/100/19/10954.full.pdf
Extended anti–PECAM-1 mAb therapy significantly reduces tumor mitotic rates, but not tumor angiogenic or tumor apoptotic rates in mice bearing advanced tumor metastases

Extended anti–PECAM-1 mAb therapy significantly reduces tumor mitotic rates, but not tumor angiogenic or tumor apoptotic rates in mice bearing advanced tumor metastases

www.pnas.org/content/107/43/18616.full.pdf

B16-F10 (P < 0.005) tumor metastases. Thus, although anti–PECAM-1 mAb 390 reduces ...
but has no affect on angiogenesis within advanced tumor metastases. As Fig. 2A illustrates, tumor metastases increase in size rapidly during the very late stages of metastatic

Oct 2010 | Proceedings of the National Academy of Sciences
Original Url: http://www.pnas.org/content/107/43/18616.full.pdf
Extended anti–PECAM-1 mAb therapy significantly reduces tumor mitotic rates, but not tumor angiogenic or tumor apoptotic rates in mice bearing advanced tumor metastases

Extended anti–PECAM-1 mAb therapy significantly reduces tumor mitotic rates, but not tumor angiogenic or tumor apoptotic rates in mice bearing advanced tumor metastases

www.pnas.org/content/107/43/18616.full.pdf

B16-F10 (P < 0.005) tumor metastases. Thus, although anti–PECAM-1 mAb 390 reduces ...
but has no affect on angiogenesis within advanced tumor metastases. As Fig. 2A illustrates, tumor metastases increase in size rapidly during the very late stages of metastatic

Oct 2010 | Proceedings of the National Academy of Sciences
Original Url: http://www.pnas.org/content/107/43/18616.full.pdf
MSP increases metastatic frequency of PyMT tumors to lung, lymph nodes, spleen, and bones

MSP increases metastatic frequency of PyMT tumors to lung, lymph nodes, spleen, and bones

www.pnas.org/content/104/18/7570.full.pdf

expressing MSP, and never metastasized to bone (Table 1). Liver metastases were observed ...
metastases in lung, bone, and lymphatics. (E and F) Fluorescent whole-mount images of larger bone metastases in mice from which the primary tumors (PyMT MSP ...
with an increase in osteoclasts at sites of bone metastases in vivo. Coordinate Overexpression

Jan 2007 | Proceedings of the National Academy of Sciences
Original Url: http://www.pnas.org/content/104/18/7570.full.pdf
Metastatic progression of B16-F10 melanoma tumors in reciprocal bone marrow chimeric mice reveals that VEC PECAM-1 mediates its prometastatic effects. Shown are lungs from animals injected with B16-F10 melanoma cells. The following animals were studied: (A) WT mice, (B) WT mice reconstituted with PECAM-1–KO marrow (WTEC-KOBM,), (C) PECAM-1–KO mice, and (D) PECAM-1– KO mice reconstituted with WT marrow ...

Metastatic progression of B16-F10 melanoma tumors in reciprocal bone marrow chimeric mice reveals that VEC PECAM-1 mediates its prometastatic effects. Shown are lungs from animals injected with B16- ...

www.pnas.org/content/107/43/18616.full.pdf

destructive growth of already well-established metastases (5). The molecular determinants ...
factors drive the lethal progression of advanced tumor metastases. Anti–PECAM-1 m ...
proliferation within these advanced metastases. This model is supported by each

Oct 2010 | Proceedings of the National Academy of Sciences
Original Url: http://www.pnas.org/content/107/43/18616.full.pdf
Bone-active factors produced by ZR-75-1 and MDA-MB-231 cell lines in vitro

Bone-active factors produced by ZR-75-1 and MDA-MB-231 cell lines in vitro

www.pnas.org/content/100/19/10954.full.pdf

metastases: total tumor area, total bone area, new bone area, and osteoclast number ...
Table 1. Bone-active factors produced by ZR-75-1 and MDA-MB-231 cell lines in vitro ZR-75-1 Bone metastases TGF (latent) bioassay of CM TGF (active) bioassay of CM TGF 1 (latent) ELISA of CM TGF 2 (latent) ELISA of CM BMP-2 (RNA) BMP-3 (RNA ...
KVP for 5 s by using a Faxitron Digital Radiographic Inspection unit (22). Bone Histology and Histomorphometry. Fore- and hindlimb bones were fixed in 10% buffered

Sep 2003 | Proceedings of the National Academy of Sciences
Original Url: http://www.pnas.org/content/100/19/10954.full.pdf
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