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Data & statistics on c-MET/HGF Inhibitors – 3445 results
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A MET Kinase Inhibitor Abrogates HGF Suppression of IL-6 Using an optimal dose of the MET inhibitor SU11274 (1 µg), BMM were pretreated for 2 hours before an overnight incubation with 10 and 100 pg HGF and 24 hour stimulation with LPS. Results are representative of the mean (± SEM) of three independent experiments done in triplicate. *, p = 0.02 vs. the respective control group.

A MET Kinase Inhibitor Abrogates HGF Suppression of IL-6 Using an optimal dose of the MET inhibitor SU11274 (1 µg), BMM were pretreated for 2 hours before an overnight incubation with 10 and 100 pg ...

etd.library.pitt.edu/ETD/available/etd-11092010-140358/unrestricted/CoudrietGM_ETD_2010.pdf

effects by the MET inhibitor as the cause for the IL-6 inhibition and to further study the important role HGF plays in tempering the acute inflammatory response, conditional MET ...
inhibitor whereby the suppressive effect of HGF on IL-6 production was significantly

Nov 2010 | etd.library.pitt.edu
Original Url: http://etd.library.pitt.edu/ETD/available/etd-11092010-140358/unrestricted/CoudrietGM_ETD_2010.pdf
Role of Met signaling in MIECP. Phosphorylation kinetics of endothelial Met, Flk1, and ERK after interaction with monocytes (a). Inhibition of HGF or Met by neutralizing antibodies inhibit MIECP- and HGF-induced EC proliferation (b). Met inhibitor SU1172 and Met siRNA transfection partially inhibit MIECP (c). (n 3, *significantly lower than MIECP control, { significantly lower than HGF control, P ...
22 more results from this site ▶

Role of Met signaling in MIECP. Phosphorylation kinetics of endothelial Met, Flk1, and ERK after interaction with monocytes (a). Inhibition of HGF or Met by neutralizing antibodies inhibit MIECP- and ...

atvb.ahajournals.org/cgi/reprint/28/1/97.pdf

/L SOV, and protease inhibitor cocktail). Phosphorylation of Met, Flk1, and ERK42/44 ...
in a biphasic phosphorylation of Met. An early phosphorylation of Met is apparent on contact ...
binding between ECs and monocytes then the second phosphorylation of Met follows

Dec 2007 | Arteriosclerosis, Thrombosis, and Vascular Biology – 22 more results from this site
Original Url: http://atvb.ahajournals.org/cgi/reprint/28/1/97.pdf
Substrate Dependent Effects of c-Met Inhibitors on HGF-induced Cell Migration

Substrate Dependent Effects of c-Met Inhibitors on HGF-induced Cell Migration

www.platypustech.com/ASCB_cMet_web.pdf

on Collagen I was demonstrated. The c-Met inhibitor PHA-665752 inhibits HGF-stimulated ...
I is Diminished by c-Met Inhibitors - Quantitation and Visualization by High Content Imager ...
to illustrate cell morphology following c-Met inhibitor treatment (C).

Dec 2008 | Platypus Technologies | Bringing Science to the Surface
Original Url: http://www.platypustech.com/ASCB_cMet_web.pdf
Substrate Dependent Effects of c-Met Inhibitors on HGF-induced Cell Migration

Substrate Dependent Effects of c-Met Inhibitors on HGF-induced Cell Migration

www.amsbio.com/presentation/ASCB_cMet_email.pdf

were acquired at 20X to illustrate cell morphology following c-Met inhibitor treatment ...
the number of cells in a fixed area overlaying the detection zone. Both c-Met inhibitors ...
A dissolved the cytoskeletal structure, while the c-Met inhibitors did not appear

Feb 2009 | amsbio (AMS Biotechnology) - Your source for life science products and services. Heparanase, Zymolyase, Antibody, Antibodies,
Original Url: http://www.amsbio.com/presentation/ASCB_cMet_email.pdf
A) Neutralizing antibodies against HGF (10 µg/mL) or cMet (2 µg/mL) inhibited INA-6 cell migration to control levels. Isotype control antibody (10 µg/mL) was used. The c-Met inhibitor PHA 665752 (50 nM) and the isotype variant of HGF, NK1 (100 ng/mL), reduced HGF-mediated cell migration. (B) Neutralizing antibody against the VLA4-integrin α4 sub-unit (0.1 µg/mL) reduced HGF-mediated cell migration ...
10 more results from this site ▶

A) Neutralizing antibodies against HGF (10 µg/mL) or cMet (2 µg/mL) inhibited INA-6 cell migration to control levels. Isotype control antibody (10 µg/mL) was used. The c-Met inhibitor PHA 665752 (50 ...

www.haematologica.org/cgi/reprint/haematol.11867v2.pdf

activation in INA-6 cells.13 The PI3K inhibitors wortmannin and LY2940002 blocked HGF ...
/STAT3 inhibitor AG490 did not influence HGF-mediated migration HGF promotes ...
C No inhibitor Anti-VLA4 Lv294002 Wortmannin SH-5 Isotype IgG Control HGF (150 ng/mL) Relative migration (%) No inhibitor PD98059 U0126 Rapamycin AG490 DMSO

Mar 2008 | Haematologica – 10 more results from this site
Original Url: http://www.haematologica.org/cgi/reprint/haematol.11867v2.pdf
The effect of HGF and MEK1/2 inhibitor (U0126) on cell proliferation in HuCCA1 cells transfected with c-Met siRNA and control siRNA. RMCCA1 and HuCCA1 transfected with the c-Met siRNA and control siRNA for 48 h were treated with and without U0126 and then stimulated with 40 ng/mL of HGF for 24 h. Cell proliferation assays were determined by WST-1. The data represent the average results from three individual ...

The effect of HGF and MEK1/2 inhibitor (U0126) on cell proliferation in HuCCA1 cells transfected with c-Met siRNA and control siRNA. RMCCA1 and HuCCA1 transfected with the c-Met siRNA and control ...

www.sc.mahidol.ac.th/scbc/bc_internet/Publication/829.pdf

Activation of c-Met with HGF had no effect on HuCCA-1 and RMCCA1 cell proliferation. Furthermore, the treatment of U0126 or c-Met siRNA to cholangiocarcinoma ...
the mechanism by which c-Met siRNA or U0126 inhibited the HGF-induced invasion

Oct 2006 | Faculty of Science at Mahidol University, THAILAND - Wisdom of the Land
Original Url: http://www.sc.mahidol.ac.th/scbc/bc_internet/Publication/829.pdf
Required for HGF-induced uveal melanoma cell migration. Transwell migration assay of uveal melanoma cell lines was carried out. Blocking antibody against c-Met (10 g/mL) or PI3K inhibitor Ly29002 (10 M) was added, together with HGF, in the lower chamber. (A) Cell morphology was observed by staining with hematoxylin and eosin. (B) The number of cells that had migrated through the pores was quantified ...
35 more results from this site ▶

Required for HGF-induced uveal melanoma cell migration. Transwell migration assay of uveal melanoma cell lines was carried out. Blocking antibody against c-Met (10 g/mL) or PI3K inhibitor Ly29002 (10 ...

www.iovs.org/content/49/2/497.full.pdf

that Akt is activated by HGF, not only in a PI3K signaling pathway-dependent manner ...
of AKT by HGF in M17 and SP6.5 cells. When M17 and SP6.5 cells were treated with different concentrations of a PI3K inhibitor, Ly294002, HGFinduced Akt activation in M17

Jan 2008 | Investigative Ophthalmology & Visual Science – 35 more results from this site
Original Url: http://www.iovs.org/content/49/2/497.full.pdf
Ligand-induced ubiquitination of Met can occur in the presence of proteasome inhibitors, although subtle differences in the pattern of ubiquitination are apparent. HeLa cells were cultured in medium with or without HGF/SF as indicated. Equal quantities of lysates from cells harvested at the indicated times after HGF/SF addition were immunoprecipitated, resolved by SDS-PAGE on 5% or 8% gels, and examined ...
22 more results from this site ▶

Ligand-induced ubiquitination of Met can occur in the presence of proteasome inhibitors, although subtle differences in the pattern of ubiquitination are apparent. HeLa cells were cultured in medium ...

www.molbiolcell.org/cgi/reprint/14/4/1346.pdf

of free ubiquitin. We have analyzed both HGF-dependent ubiquitination of Met after ...
Met Ubiquitination and Lactacystin Ubiquitination has recently been identified ...
, and indeed the Met receptor is ubiquitinated after stimulation (Jeffers et al., 1997b

Mar 2003 | Molecular Biology of the Cell – 22 more results from this site
Original Url: http://www.molbiolcell.org/cgi/reprint/14/4/1346.pdf
PGE2 transactivates c-Met-R in colon cancer cells. Serum-starved LoVo (A) and Caco-2 (B) cells were treated with vehicle or AG 1478 (EGFR inhibitor), followed by incubation with or without PGE2 , EGF, or HGF. Top: c-Met-R phosphorylation was determined by immunoprecipitation (c-Met-R mAb) and immunoblotting with anti-phosphotyrosine antibody. Middle: Total c-Met-R in immunoprecipitates was determined ...
21 more results from this site ▶

PGE2 transactivates c-Met-R in colon cancer cells. Serum-starved LoVo (A) and Caco-2 (B) cells were treated with vehicle or AG 1478 (EGFR inhibitor), followed by incubation with or without PGE2 , EGF ...

www.fasebj.org/cgi/reprint/17/12/1640.pdf

Vo) with PGE2 (10 M, 5 min) significantly increased c-Met-R association with -catenin in Lo ...
compared with vehicle-treated control cells. Increased association of c-Met ...
(Fig. 3A). Similar results showing increased c-Met-R association with -catenin

Aug 2003 | The FASEBJ Journal - Federation of American Societies for Experimental Biology. – 21 more results from this site
Original Url: http://www.fasebj.org/cgi/reprint/17/12/1640.pdf
It was evident that the c-Met-selective inhibitor was effective against all but one of the nine cell lines tested, with IC50 ranging from f0.8 to 4.4 Amol/L. The H661 cell line, negative for cMet expression, showed negligible inhibition of cell growth and viability by SU11274 up to 5 Amol/L. Using SU11274, we have further defined its inhibitory effects on the c-Met/HGF signaling pathway in the two ...
39 more results from this site ▶

It was evident that the c-Met-selective inhibitor was effective against all but one of the nine cell lines tested, with IC50 ranging from f0.8 to 4.4 Amol/L. The H661 cell line, negative for cMet ...

cancerres.aacrjournals.org/content/65/4/1479.full.pdf

technique (Fig. 5A). The HGF-induced activation of the pMet [Y1003] and [Y1230/1234/1235 ...
5-diphenyltetrazolium bromide assay. SU11274 Inhibits Cell Viability and c-Met/HGF Signaling of NSCLC Cells. SU11274 is a highly specific inhibitor of c-Met with in vitro IC50

Jan 2005 | Cancer Research – 39 more results from this site
Original Url: http://cancerres.aacrjournals.org/content/65/4/1479.full.pdf
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